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It is suggested that individuals be dealt with for no less than 4 cycles. Having said that, total or partial reaction may perhaps require in excess of four procedure cycles. Treatment may be ongoing providing the individual carries on to benefit.
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Watch people for hematologic response and renal toxicities [see WARNINGS AND Safeguards], and hold off or minimize dosage if required as explained underneath.
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VIDAZA can be a pyrimidine nucleoside analog of cytidine. VIDAZA is considered to exert its antineoplastic consequences by leading to hypomethylation of DNA and immediate cytotoxicity on irregular hematopoietic cells from the bone marrow. The focus of azacitidine needed for max inhibition of DNA methylation in vitro would not trigger big suppression of DNA synthesis.
Azacitidine is contraindicated in people with Innovative malignant hepatic tumors [see CONTRAINDICATIONS]. Monitor liver chemistries prior to initiation of therapy and with Just about every cycle.
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The occasions solved devoid of sequelae, and the right dose was resumed the subsequent working day. In the event of overdosage, the patient should be monitored with correct blood counts and may receive supportive therapy, as needed. There is no recognised particular antidote for VIDAZA overdosage.
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This medication is injected once per day for seven days in a very row or as directed by your health practitioner. A seven-day system of the medication is named a cycle. This cycle is repeated each four weeks internet based on your response and blood checks.